Trulance vs. Linzess: A Comprehensive Comparison for Gastrointestinal Relief

Editorial Staff
Editorial Staff Health
6 Min Read

When it comes to managing gastrointestinal disorders such as IBS-C or CIC, it’s crucial to have effective treatment options. Trulance vs Linzess are two medications that healthcare providers commonly prescribe for these conditions. Both aim to alleviate the symptoms associated with these disorders, but they work in slightly different ways.

What Is Trulance?

2.1 Mechanism of Action

Trulance, also known by its generic name plecanatide, is a medication that falls under the category of guanylate cyclase-C agonists. It works by increasing the amount of chloride and water in the intestines, making it easier for stool to pass through the bowels. This mechanism helps relieve constipation associated with IBS-C and CIC.

2.2 Indications

Trulance is primarily indicated for the treatment of IBS-C and CIC in adults. It is available in tablet form and is typically taken once daily with or without food.

What Is Linzess?

3.1 Mechanism of Action

Linzess, with its generic name linaclotide, is another medication commonly used to treat IBS-C and CIC. It belongs to the class of medications called guanylate cyclase-C agonists, just like Trulance. Linzess works by increasing the secretion of fluid into the intestines and promoting bowel movements, thus alleviating constipation.

3.2 Indications

Linzess is indicated for the treatment of both IBS-C and CIC in adults. It is available in capsule form and is usually taken once daily on an empty stomach, at least 30 minutes before the first meal of the day.


Both Linzess vs Trulance have demonstrated effectiveness in relieving symptoms of IBS-C and CIC. However, individual responses to these medications can vary, so it’s essential to discuss your specific case with your healthcare provider.

Safety Profile

5.1 Common Side Effects

Common side effects of Trulance and Linzess may include diarrhea, abdominal pain, and flatulence. These side effects are generally mild to moderate in nature.

5.2 Serious Side Effects

While both medications are generally well-tolerated, it’s essential to be aware of potential serious side effects such as severe diarrhea or allergic reactions. If you experience any unusual or severe symptoms, seek medical attention immediately.

Dosage and Administration

6.1 Trulance Dosage

The recommended dosage for Trulance is usually 3 mg once daily. Your healthcare provider may adjust the dose based on your response and tolerability.

6.2 Linzess Dosage

Linzess is typically prescribed at a dosage of 145 mcg once daily. Like Trulance, the dose may be adjusted by your healthcare provider as needed.

Cost Comparison

The cost of Trulance and Linzess can vary depending on your location, insurance coverage, and the pharmacy you use. It’s advisable to check with your insurance provider and compare prices to make an informed decision.

Patient Experiences

Many individuals have reported positive experiences with both Trulance and Linzess in relieving their gastrointestinal symptoms. However, as with any medication, individual responses can vary.

Which One Should You Choose?

The choice between Trulance and Linzess depends on various factors, including your specific symptoms, medical history, and personal preferences. It’s essential to consult with your healthcare provider to determine which medication is the most suitable for your condition.


In summary, Trulance and Linzess are both effective medications for managing IBS-C and CIC. They have similar mechanisms of action, but individual responses and preferences may vary. Your healthcare provider can help you make the best choice based on your unique situation.


Are Trulance and Linzess available in generic forms?

Trulance is available as plecanatide, its generic form. However, Linzess is still under patent protection and does not have a generic equivalent as of now.

Can I take Trulance or Linzess if I’m pregnant or breastfeeding?

It’s essential to discuss your pregnancy or breastfeeding status with your healthcare provider before taking either medication, as safety data in these situations may be limited.

How long does it typically take for Trulance and Linzess to start working?

The time it takes for these medications to provide relief can vary from person to person. Some individuals may experience improvement within a few days, while others may take a few weeks.

Are there any dietary restrictions while taking Trulance or Linzess?

Both medications are typically taken on an empty stomach, at least 30 minutes before the first meal of the day. Your healthcare provider will provide specific instructions on dosing.

Can I switch between Trulance and Linzess if one doesn’t work for me?

Switching between these medications can be an option, but it should be done under the guidance of your healthcare provider. They can assess your response and make appropriate recommendations.

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